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Semenza's research focuses on gun violence, victimization, and the connections between criminal justice exposure and health. Overarching themes in Semenza's writings include the public health consequences of the criminal justice system, firearm availability, racial disparities in violence exposure and health, and the implications of firearm policy. Semenza is a faculty affiliate with the New Jersey Center on Gun Violence Research as well as an external faculty fellow with the Health Criminology Research Consortium at Saint Louis University. He is also a faculty affiliate and board member with the Health Sciences Center at Rutgers – Camden.