Histed

Mark H. Histed

Adjunct Professor of Neuroscience and Cognitive Science, University of Maryland-College Park
Areas of Expertise:

About Mark

Histed is a senior investigator and group leader at the National Institute of Mental Health, NIH. His neuroscience work aims to understand how the trillions of connections in our brains control information processing, memory, and learning, using cutting-edge laser optical methods and conceptual analogies to AI. His policy work focuses on how public goods are provisioned by societies, and how public governance can resist politicization and serve democratic ends. In advocacy areas, he was a co-founder of the Media and Democracy Project and the News Dollars director for Democracy Policy Network.

Contributions

How Congress Can Restore the Independence of US Science

  • Natalie B. Aviles

In the News

Opinion: "An Ascendant Constitutional Theory Is a Threat to American Science," Mark H. Histed, The Atlantic, June 17, 2026.
Guest on Court Accountability Action , February 23, 2026.
Opinion: "American Biomedical Science in 2026," Mark H. Histed, Can We Still Govern? , January 27, 2026.
Guest on Theory of Change, October 28, 2025.
Quoted by Science News Staff in "As U.S. Shutdown Drags On, ‘It’s Just One Blow After Another’," Science, October 10, 2025.
Quoted by Hannah Harris Green in "Trump Cuts to Science Research Threaten His Administration’s Own AI Action Plan," The Guardian , August 14, 2025.
Opinion: "There is a Local News Crisis in the District, The Council Can Help Fix It," Mark H. Histed (with Anna Brugmann ), The Washington Informer, April 4, 2024.
Quoted by Sara Fischer and Cuneyt Dil in "D.C. Lawmakers to Introduce New Bill Funding Local News Via Vouchers," Axios, October 20, 2023.
Guest on What Works, March 17, 2023.
Opinion: "How a News Voucher System Could Revitalize American Journalism," Mark H. Histed, In These Times, February 21, 2022.

Publications

"Active Filtering of Sequences of Neural Activity by Recurrent Circuits of Sensory Cortex" (with Claire E. Deveau, Zhe Zhou, Patrick K. LaFosse, Yao Deng, S. Mirbagheri, and Nicholas Steinmetz). Neuron (2026).

Shows that parts of the brain involved in processing senses actively filter incoming signals, helping the brain focus on meaningful patterns instead of just reacting to everything it receives.

"Presidentialist Governance is Incompatible with the American Science Superpower" (with Natalie B. Aviles), Social Science Research Network, January 2026.

Argues that the U.S. political system—where a president holds significant power—makes it harder to consistently support and grow scientific research, which could weaken America’s leadership in science.

"Active Filtering: A Predictive Function of Recurrent Circuits of Sensory Cortex" Annual Review of Vision Science 11, no. 1 (2025).

Explains how certain brain circuits don’t just react to sensory input—they predict what’s coming next, helping us process information more efficiently.

"Single Cell Optogenetics Reveals Attenuation-By-Suppression in Visual Cortical Neurons" (with Patrick K. LaFosse, Zhe Zhou, Victoria M. Scott, and Yao Deng). Proceedings of the National Academy of Sciences of the United States of America 121, no. 45 (2024).

Finds that activating individual brain cells can actually reduce activity in nearby cells, showing how the brain fine-tunes visual processing by dampening certain signals.

"Local News Dollars", Democracy Policy Network, 2023.

Argues that investing public money into local journalism can strengthen communities and improve democracy by ensuring people have access to reliable local news.