Peggy Compton

Peggy Compton

Professor of Nursing, University of Pennsylvania
Areas of Expertise:

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About Peggy

Compton's area of clinical expertise is the intersection of opioids, addiction and pain, and her novel data have contributed to a growing body of literature on the phenomenon of opioid-induced hyperalgesia, as well as informed guidelines for the management of pain in persons with opioid addiction.


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In the News

Peggy Compton's research on Joel Wolfram, "Leftover Painkillers Driving Opioid Crisis, Penn Researcher Says," 90.5 WESA Pittsburgh, September 18, 2017.
Peggy Compton quoted by Moriah Balingit, "Aiming to Curb Drug Abuse, New Program Will Teach Teens the Science of Addiction" Washington Post, October 25, 2016.


"Addressing the Potential for Perioperative Relapse in Those Recovering from Opioid Use Disorder" (with Joseph Myers). Pain Medicine (2017).

Finds that one in 10 surgical patients is still using opioids one year postdischarge despite expectations that postoperative pain subsides within the first month following surgery

"The Epidemic of Prescription Opioid Abuse, the Subsequent Rising Prevalence of Heroin Use, and the Federal Response" (with Andrew B. Kanouse). Journal of Pain & Palliative Care Pharmocotherapy 29, no. 2 (2015): 201-114.

Reviews and explores the combination of factors of events that led to the current “epidemic” of prescription opioid abuse and overdose deaths, as well as the subsequent resurgence of heroin use among opioid addicts.

"The Effect of Motivational Interviewing on Prescription Opioid Adherence among Older Adults with Chronic Pain" (with Yu-Ping Chang, Pamela Almeter, and Chester H. Fox). Perspectives in Psychiatric Care 51, no. 3 (2014): 211-219.

Tests the effect of office‐based motivational interviewing (MI) on prescription opioid adherence in older adults with chronic pain. Finds that participants demonstrated a significantly reduced risk of prescription opioid misuse, decreased substance use, increased self‐efficacy, increased motivation to change, and decreased depression at both the post‐test and 1‐month follow‐up.

"College on Problems of Drug Dependence Taskforce on Prescription Opioid Non-Medical Use and Abuse: Position Statement" (with George Bigelow, James Zacny, Kathleen Foley, Martin Iguchi, and Christine Sannerud). Drug and Alcohol Dependnece 69, no. 3 (2003): 215-232.

Addresses the issues related to the non-medical use and abuse of prescription opioids.